Phagocytosed malaria pigment: Difference between revisions
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<span style="font-size:90%">The malaria pigment formed by parasites to detoxify the iron contained in the haem portion of digested haemoglobin is an insoluble brown or golden clump or clumps of pigment. Following schizont rupture this insoluble material is released into the circulation. Below is an image of a rupturing schizont, the red cell membrane will soon | <span style="font-size:90%">The malaria pigment formed by parasites to detoxify the iron contained in the haem portion of digested haemoglobin is an insoluble brown or golden clump or clumps of pigment. Following schizont rupture this insoluble material is released into the circulation. Below is an image of a rupturing schizont, the red cell membrane will soon lose its integrity releasing both merozoites the pigment (arrowed) will also be released into blood.</span></br></br> | ||
<gallery mode="nolines" widths="220px" heights="220px" > | <gallery mode="nolines" widths="220px" heights="220px" > | ||
File:Mp1.jpg|<span style="font-size:90%">Rupturing schizont of ''P.malariae''</span>|link={{filepath:Mp1.jpg}} | File:Mp1.jpg|<span style="font-size:90%">Rupturing schizont of ''P.malariae''</span>|link={{filepath:Mp1.jpg}} | ||
</gallery> | </gallery> | ||
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<span style="font-size:90%">The released pigment is seen as "foreign" material and is recognised and ingested by phagocytes (neutrophils or monocytes) where it appears | <span style="font-size:90%">The released pigment is seen as "foreign" material by the immune system and is recognised and ingested by phagocytes (neutrophils or monocytes) where it appears in the cytoplasm and may be visible on thin or thick malaria film preparations. The appearance has some species-specificity, but of more importance when found it should be regarded as evidence to support malaria infection.</span> | ||
</br></br> | </br></br> | ||
<gallery mode="nolines" widths="220px" heights="220px" > | <gallery mode="nolines" widths="220px" heights="220px" > | ||
Revision as of 10:04, 21 March 2025
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| Phagocytosis of malaria pigment
The malaria pigment formed by parasites to detoxify the iron contained in the haem portion of digested haemoglobin is an insoluble brown or golden clump or clumps of pigment. Following schizont rupture this insoluble material is released into the circulation. Below is an image of a rupturing schizont, the red cell membrane will soon lose its integrity releasing both merozoites the pigment (arrowed) will also be released into blood.
The released pigment is seen as "foreign" material by the immune system and is recognised and ingested by phagocytes (neutrophils or monocytes) where it appears in the cytoplasm and may be visible on thin or thick malaria film preparations. The appearance has some species-specificity, but of more importance when found it should be regarded as evidence to support malaria infection.
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