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|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Malaria Pigment''' (haemozoin)</span>
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Amoeboid forms'''</span>
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<gallery mode="nolines" widths="220px" heights="220px" >
File:Pig1.jpg|link={{filepath:MPi1.jpg}}
</gallery>
<span style="font-size:90%>A solid and angular late trophozoite form of ''P.malariae''. Note the golden pigment in separate clumps of granules distributed over the parasite surface (arrowed).</span>
<span style=font-size:90%>'''Description'''</span>
<span style="font-size:90%>During their development malarial parasites metabolise the haemoglobin within erythrocytes to support their growth. Evetually infected cells at late stages of parasite development red cell may have no visible haemoglobin. As part of that process the parasite must "detoxify" the iron component of the haem element. This process creates a detoxified iron containing protein "haemozoin" which is visible as pigment - as you might expect this is most visible at late stages of parasite development.</span>


<span style="font-size:90%>'''Species significance'''</span>
<span style="font-size:90%>As trophozoites of ''P.vivax'' mature, they lose their ring form and acquire an irregular form that is said to resemble an amoeba with extended processes. Other features of the species such as enlarged irregular red cells and typical Schuffner's dots also develop at the same time. This parasite appearance is fairly specific for ''P.vivax'' that is helpful to indicate this diagnosis. Early signs may be seen in early trophozoites.</span>
<span style="font-size:90%>Pigment may vary in colour and may be clumped or scattered as individual small masses depending on species; in some instances this can help (most obviously in the central clump seen in the "daisy head" schizonts of ''P.malariae''). Generally however, the form of the pigment is less useful than other features in determining species.</span>
 
 
<span style="font-size:90%>'''Additional images'''</span>
<span style="font-size:90%>Pigment in different stages of parasite development</span>




<gallery mode="nolines" widths="220px" heights="220px" >
<gallery mode="nolines" widths="220px" heights="220px" >
File:Pig2.jpg|Gametocyte ''P.malariae''|link={{filepath:Pig2.jpg}}
File:amoeboid1.jpg|A|link={{filepath:amoeboid1.jpg}}
File:Pig3.jpg|Schizont ''P.ovale''|link={{filepath:Pig3.jpg}}
File:amoeboid2.jpg|B|link={{filepath:amoeboid2.jpg}}
File:Pig4.jpg|Trophozoite ''P.ovale''|link={{filepath:Pig4.jpg}}
File:Pig5.jpg|Gametocyte ''P.falciparum''|link={{filepath:Pig5.jpg}}
</gallery>
</gallery>
<span style="font-size:90%>''Amoeboid forms: an early trophozoite begins to become more irregular though still a partly recognisable "ring" (A); this late trophozoite has a more typical irregular "amoeboid" form (B)''
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Latest revision as of 18:15, 6 January 2025

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Amoeboid forms

As trophozoites of P.vivax mature, they lose their ring form and acquire an irregular form that is said to resemble an amoeba with extended processes. Other features of the species such as enlarged irregular red cells and typical Schuffner's dots also develop at the same time. This parasite appearance is fairly specific for P.vivax that is helpful to indicate this diagnosis. Early signs may be seen in early trophozoites.


  • A

    A

  • B

    B

Amoeboid forms: an early trophozoite begins to become more irregular though still a partly recognisable "ring" (A); this late trophozoite has a more typical irregular "amoeboid" form (B)

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