False positive reaction in RDT tests
From MalariaETC
Navigation
Main Malaria Index
>RDT main page
>>Single Band Tests
>>>Current page: False positive reactions
| Cross-reactive antibodies
Cross-reactive antibodies are antibodies that interfere with RDT tests to cause a band to appear in the absence of a malaria infection - a "false positive". They are though to ariase as a result as a result of them forming an immune complex with labelled test antibodies and the antibodies of the detection line - so causing a band to appear in the test area in the absence of a malarial infection. These cross-reactive antibodies may arise following infection with another tropical organisms, or may be "polyreactive antibodies" found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse antibody (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer. |