Multiplexed detection strategies may be used in some circumstances to optimase performance for local need:
(a) Where both P.falciparum and P.vivax are highly prevalent, then tests with specificity for each species may prove valuable - P.falciparum (HRP2) and P.vivax (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.
(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.