HRP2 gene deletion

Gene deletion mutation These gene-deletion are specific for HRP2 and HRP3 genes: Described in South America, sub-Saharan Africa and Asia, deletions of HRP2 prevent its synthesis, causing reduced sensitivity or false negative test results. In high parasitaemia the tests may still work in the presence of single gene deletions of HRP2 since the test also detects HRP3. However, deletions affecting both HRP2 and HRP3 genes are now recognised and cause negative tests. The use of HRP to detect malaria may not be appropriate where the HRP2 deletion rate is 5% or greater. Tests that combine HRP2 is combined with antibody (either aldolase or pLDH) may overcome these problems.