| RDT Quiz A Q2
Shown below is an RDT test. This uses a pan-malarial antibody (labelled Pan) and a P.falciparum species-specific antibody (labelled Sp). The test has been used to assess a patient and the positive bands are shown on the figure.
{When comparing RDT tests and morphology in the diagnosis of malaria which statements are true?
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- RDT tests offer superior species identification compared with microscopy
+ Well-trained microscopists diagnose malaria with equivalent or better sensitivity than RDT
+ MDT tests offer a more rapid initial diagnosis
+ RDT tests may be a preferred choice in some low-income countries
- RDT tests provide a more accurate assessment of the % of infected red cells
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| Explanation of correct answer (click "Expand")
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In ideal conditions a well-trained microscopist with experience in malaria, viewing a well-prepared thick blood film using a good quality microscope may detect with equal or better sensitivity than an RDT test.
In less ideal conditions where equipment, staining quality, or microscopic experience is less good, then RDTs may have equivalent or superior sensitivity to microscopy (including many malarial endemic regions where microscopy may be unavailable or where the sensitivity of microscopy is limited by training, equipment or facilities). RDTs aso provide a more rapid turnaround time allowing emergency use and rapid decision-making.
For species identification thin films are preferred to thick films or RTDS (including mixed infections), as they also allow more accurate identification of sepecies and the % of infected red-cells (for P.falciparum or P.knowlesi).
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