Actions

Prozone effect alt

From MalariaETC

Revision as of 14:17, 30 October 2024 by Admin (talk | contribs) (Created page with "{{DISPLAYTITLE:<span style="position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);">{{FULLPAGENAME}}</span>}} ---- '''Navigation'''</br> <span style="font-size:90%">Main Malaria Index''</span></br> <span style="font-size:90%">>RDT main page''</span></br> <span style="font-size:90%">>>Multi Band Tests''</span></br> <span style="font-size:90%">>>>Curr...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Navigation
Main Malaria Index
 >RDT main page
 >>Multi Band Tests
 >>>Current page: The prozone-like effect

The prozone-like (postzone) phenomenon


The prozone-like or "postzone" phenomenon (the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen) is a very rare, but recognised effect that causes false negative results of tests.

Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.

Retrieved from "https://haematologyetc.org/index.php?title=Prozone_effect_alt&oldid=1029"