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19:53, 28 October 2024 Admin talk contribs uploaded File:RDT multi neg.jpg
19:53, 28 October 2024 Admin talk contribs created page File:RDT multi fail4.jpg
19:53, 28 October 2024 Admin talk contribs uploaded File:RDT multi fail4.jpg
19:53, 28 October 2024 Admin talk contribs created page File:RDT multi fail3.jpg
19:53, 28 October 2024 Admin talk contribs uploaded File:RDT multi fail3.jpg
19:53, 28 October 2024 Admin talk contribs created page File:RDT multi fail2.jpg
19:53, 28 October 2024 Admin talk contribs uploaded File:RDT multi fail2.jpg
19:52, 28 October 2024 Admin talk contribs created page File:RDT multi fail1.jpg
19:52, 28 October 2024 Admin talk contribs uploaded File:RDT multi fail1.jpg
17:15, 9 October 2024 Admin talk contribs created page File:RDT multi pos2.jpg
17:15, 9 October 2024 Admin talk contribs uploaded File:RDT multi pos2.jpg
17:05, 9 October 2024 Admin talk contribs created page False positive reaction in RDT tests 2 (Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation''' Main Malaria Index'' >RDT main page'' >>Multi Band Tests'' >>>Curr...")
17:04, 9 October 2024 Admin talk contribs created page Clearance of parasite antigens from blood 2 (Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation''' Main Malaria Index'' >RDT main page'' >>Multi Band Tests'' >>>Curr...")
17:02, 9 October 2024 Admin talk contribs created page Co-infection with two species2 (Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation''' Main Malaria Index'' >RDT main page'' >>Multi-Band Tests'' >>>Curr...")
10:54, 9 October 2024 Admin talk contribs created page File:RDT multi pos1.jpg
10:54, 9 October 2024 Admin talk contribs uploaded File:RDT multi pos1.jpg
17:16, 7 October 2024 Admin talk contribs created page File:RDT multi no band4.jpg
17:16, 7 October 2024 Admin talk contribs uploaded File:RDT multi no band4.jpg
17:16, 7 October 2024 Admin talk contribs created page File:RDT multi no band3.jpg
17:16, 7 October 2024 Admin talk contribs uploaded File:RDT multi no band3.jpg
17:15, 7 October 2024 Admin talk contribs created page File:RDT multi no band2.jpg
17:15, 7 October 2024 Admin talk contribs uploaded File:RDT multi no band2.jpg
17:14, 7 October 2024 Admin talk contribs created page File:RDT multi no band1.jpg
17:14, 7 October 2024 Admin talk contribs uploaded File:RDT multi no band1.jpg
09:18, 4 October 2024 Admin talk contribs created page Pan-malarial LDH and Adolase (Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation''' >Main Malaria Index'' >>RDT main page'' >>>RDT test antigens >>>Current page: '''The a...")
12:41, 3 October 2024 Admin talk contribs created page Pan-malarial aldolase (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''Pan-malarial antigens''' '''Background:''' Plasmodium aldolase (Paldolase) and plasmodium lactate dehydrogenase (PLDH) are part of glycolysis pathways in all malaria species. Since malaria parasites have sp...")
12:40, 3 October 2024 Admin talk contribs created page Pan-malarial LDH (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''Pan-malarial antigens''' '''Background:''' Plasmodium aldolase (Paldolase) and plasmodium lactate dehydrogenase (PLDH) are part of glycolysis pathways in all malaria species. Since malaria parasites have sp...")
15:32, 26 September 2024 Admin talk contribs created page False positive reaction in RDT tests (Created page with "Cross-reactive antibodies: Cross-reactive antibodies arising in other infection (usually tropical organisms, occasionally inter-species for PV), but also the presence of polyreactive antibodies found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer.")
09:31, 26 September 2024 Admin talk contribs created page Co-infection with two species (Created page with "Mixed-species malaria infections are often not recognized or underestimated. In Asia, surveys usually report that <2% of infections are mixed, whereas therapeutic studies in vivax or falciparum malaria have demonstrated a high prevalence (up to 30%) of infection with the other malaria species during convalescence, suggesting covert co-infection. In epidemiological studies, a high prevalence of cryptic mixed-malaria species infection has been detected by sensitive PCR tec...")
10:06, 24 September 2024 Admin talk contribs created page File:RDT single two band+.jpg
10:06, 24 September 2024 Admin talk contribs uploaded File:RDT single two band+.jpg
10:03, 24 September 2024 Admin talk contribs created page File:Contol RDT neg.jpg
10:03, 24 September 2024 Admin talk contribs uploaded File:Contol RDT neg.jpg
09:55, 24 September 2024 Admin talk contribs created page How do RDT tests compare to microscopy? (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''The value of RDT compared with microscopy: thick blood films''' In ideal conditions a well-trained microscopist with experience in malaria, viewing a well-prepared thick blood film us...")
17:46, 18 September 2024 Admin talk contribs created page RDT test: antigens (Created page with "{| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black" |colspan="1" style = "font-size:100%; color:black; background: gainsboro |'''THE ANTIGENS''' |} <div style="width: 95%; font-size:90%;"> {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" !colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|'''1. Species-specific antigens:''' these d...")
17:37, 18 September 2024 Admin talk contribs created page RDT test: formats of tests (Created page with "{| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black" |colspan="1" style = "font-size:100%; color:black; background: gainsboro |'''TEST FORMATS''' |} '''Single test-band RDT tests''' <gallery mode="nolines" widths=300px heights=80px> File:RDT_single.jpg||link={{filepath:RDT_single.jpg}} </gallery> This test form...")
11:33, 17 September 2024 Admin talk contribs created page Alt menu (Created page with "---- '''Navigation''' Return to Main index'' Alt menu ---- {| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black" |colspan="1" style = "font-size:100%; color:black; background: gainsboro |'''OVERVIEW''' |} RDTs detect malarial parasite antigens in the blood of infected individuals. Precise test formats can differ according t...")
15:44, 15 September 2024 Admin talk contribs created page Practical reasons for test failure (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"|'''Practical considerations ''' Bibilography: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652944/], [https://www.who.int/teams/global-malaria-programme/case-management/d...")
15:34, 15 September 2024 Admin talk contribs created page File:RDT single no band+.jpg
15:34, 15 September 2024 Admin talk contribs uploaded File:RDT single no band+.jpg
15:26, 15 September 2024 Admin talk contribs created page File:RDT single no band.jpg
15:26, 15 September 2024 Admin talk contribs uploaded File:RDT single no band.jpg
20:07, 14 September 2024 Admin talk contribs created page Interpretation guide: SINGLE BAND tests (Created page with "Invalid test No band appears in the control area Invalid test: do not interpret, consider if test was incorrectly performed or incorrectly stored For valid tests (1) A band appears in the species-specific area only Most common: the species is present and no other species is present Possible alternatives: There is a dual infection but the second species is not detected by the pan-species antibody* This is a false positive band* (2) No band present in species-specific ar...")
14:12, 13 September 2024 Admin talk contribs created page General and specific limitations of RDT tests (Created page with "In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards,...")
14:09, 13 September 2024 Admin talk contribs created page Emerging strategies and options (Created page with "In order to improve test sensitivities when dealing with non-ideal biomarkers, manufacturers of RDTs often seek to use the multiplexed detection of distinct, species-specific antigens. In the case of malaria, RDTs are often multiplexed to detect HRP2 and the P. vivax variant of parasite lactate dehydrogenase (Pv-pLDH), to distinguish between infections by P. falciparum and P. vivax. Alternatively, tests can be multiplexed to select for Pf-pLDH and HRP2, which yields high...")
16:51, 12 September 2024 Admin talk contribs created page Practical reasons for poor RDT performance (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''The value of RDT compared with microscopy: thick blood films''' Assay quality: not all are the same WHO Heat stability of the RDT card: storage Age of card or reagent:storage Lot to lot variability in assay qua...")
15:42, 9 September 2024 Admin talk contribs created page Pracical reasons for poor RDT performance (Created page with "Assay quality: not all are the same WHO Heat stability of the RDT card: storage Age of card or reagent:storage Lot to lot variability in assay quality Operator-Specific Factors Operator-Inappropriate placement of reagent or blood drop Operator-Interpreting faint line")
10:13, 9 September 2024 Admin talk contribs created page Interpretation guide: MULTI BAND tests (Created page with "Invalid test No band appears in the control area Invalid test: do not interpret, consider if test was incorrectly performed or incorrectly stored For valid tests (1) A band appears in the species-specific area only Most common: the species is present and no other species is present Possible alternatives: There is a dual infection but the second species is not detected by the pan-species antibody* This is a false positive band* (2) No band present in species-specific...")
16:36, 29 August 2024 Admin talk contribs created page Microscopy and RDT test sensitivity (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''The value of RDT compared with microscopy''' ---- '''Conclusions'''")
10:07, 29 August 2024 Admin talk contribs created page False negative results and the prozone effect (Created page with "{| class="wikitable" style="border-style: solid; border-width: 4px; border-color:green" |colspan="1" style = "font-size:110%; color:black; background: white"| The prozone effect is a very rare, but recognised effect that causes false negative results of tests. ---- Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) te...")

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