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15:26, 15 September 2024 Admin talk contribs created page File:RDT single no band.jpg
15:26, 15 September 2024 Admin talk contribs uploaded File:RDT single no band.jpg
20:07, 14 September 2024 Admin talk contribs created page Interpretation guide: SINGLE BAND tests (Created page with "Invalid test No band appears in the control area Invalid test: do not interpret, consider if test was incorrectly performed or incorrectly stored For valid tests (1) A band appears in the species-specific area only Most common: the species is present and no other species is present Possible alternatives: There is a dual infection but the second species is not detected by the pan-species antibody* This is a false positive band* (2) No band present in species-specific ar...")
14:12, 13 September 2024 Admin talk contribs created page General and specific limitations of RDT tests (Created page with "In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards,...")
14:09, 13 September 2024 Admin talk contribs created page Emerging strategies and options (Created page with "In order to improve test sensitivities when dealing with non-ideal biomarkers, manufacturers of RDTs often seek to use the multiplexed detection of distinct, species-specific antigens. In the case of malaria, RDTs are often multiplexed to detect HRP2 and the P. vivax variant of parasite lactate dehydrogenase (Pv-pLDH), to distinguish between infections by P. falciparum and P. vivax. Alternatively, tests can be multiplexed to select for Pf-pLDH and HRP2, which yields high...")
16:51, 12 September 2024 Admin talk contribs created page Practical reasons for poor RDT performance (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''The value of RDT compared with microscopy: thick blood films''' Assay quality: not all are the same WHO Heat stability of the RDT card: storage Age of card or reagent:storage Lot to lot variability in assay qua...")
15:42, 9 September 2024 Admin talk contribs created page Pracical reasons for poor RDT performance (Created page with "Assay quality: not all are the same WHO Heat stability of the RDT card: storage Age of card or reagent:storage Lot to lot variability in assay quality Operator-Specific Factors Operator-Inappropriate placement of reagent or blood drop Operator-Interpreting faint line")
10:13, 9 September 2024 Admin talk contribs created page Interpretation guide: MULTI BAND tests (Created page with "Invalid test No band appears in the control area Invalid test: do not interpret, consider if test was incorrectly performed or incorrectly stored For valid tests (1) A band appears in the species-specific area only Most common: the species is present and no other species is present Possible alternatives: There is a dual infection but the second species is not detected by the pan-species antibody* This is a false positive band* (2) No band present in species-specific...")
16:36, 29 August 2024 Admin talk contribs created page Microscopy and RDT test sensitivity (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''The value of RDT compared with microscopy''' ---- '''Conclusions'''")
10:07, 29 August 2024 Admin talk contribs created page False negative results and the prozone effect (Created page with "{| class="wikitable" style="border-style: solid; border-width: 4px; border-color:green" |colspan="1" style = "font-size:110%; color:black; background: white"| The prozone effect is a very rare, but recognised effect that causes false negative results of tests. ---- Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) te...")
10:04, 29 August 2024 Admin talk contribs created page False negative results and HRP2 gene deletion (Created page with "{| class="wikitable" style="border-style: solid; border-width: 4px; border-color:green" |colspan="1" style = "font-size:110%; color:black; background: white"| Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing. ---- (1) Deletions of ''HRP2'' prevent its synthesis, causing reduced sensitiv...")
15:11, 23 August 2024 Admin talk contribs created page Pan-specific antigens in RDTs (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''Use of pan-malarial antigen RDTs in diagnosis'''")
15:06, 23 August 2024 Admin talk contribs created page (Pan-specific antigens in RDTs) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''Use of pan-malarial antigen RDTs in diagnosis'''")
15:04, 23 August 2024 Admin talk contribs created page (pan-specific antigens) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''Use of pan-malarial antigen RDTs in diagnosis'''")
15:02, 23 August 2024 Admin talk contribs created page Clearance of parasite antigens from blood (Created page with "{| class="wikitable" style="border-style: solid; border-width: 4px; border-color:green" |colspan="1" style = "font-size:110%; color:black; background: white"| The half-life of antigens in circulation can have practical implications for their use in diagnosis or monitoring of malaria. ---- This is a complex area which dedends on many factors including type of treatment and severity of initial infection, but it is believed that HRP2 test...")
14:40, 23 August 2024 Admin talk contribs created page Clearance of parasite antigen from blood (Created page with "{| class="wikitable" style="border-style: solid; border-width: 4px; border-color:green" |colspan="1" style = "font-size:110%; color:black; background: white"| The half-life of antigens in circulation can have practical implications for their use in diagnosis or monitoring of malaria. ---- Return to HRP2 page")
14:21, 23 August 2024 Admin talk contribs created page HRP2 gene deletion (Created page with "'''Gene deletion mutation''' These gene-deletion are specific for ''HRP2'' and ''HRP3'' genes: Described in South America, sub-Saharan Africa and Asia, deletions of ''HRP2'' prevent its synthesis, causing reduced sensitivity or false negative test results. In high parasitaemia the tests may still work in the presence of single gene deletions of ''HRP2'' since the test also detects HRP3. However, deletions affecting both HRP2 and HRP3 genes are now recognised and cause ne...")
14:15, 23 August 2024 Admin talk contribs created page Prozone effect (Created page with "The Prozone effect A very rare, but recognised effect, most often this affects HRP2 antigens and means that in very high parasitaemia (causing excess antigen), the formation of appropriate antibody-antigen complexes is prevented causing the test to appear negative.")
11:00, 23 August 2024 Admin talk contribs uploaded a new version of File:RDT multi.jpg
11:00, 23 August 2024 Admin talk contribs uploaded a new version of File:RDT single.jpg
18:51, 22 August 2024 Admin talk contribs created page File:RDT multi.jpg
18:51, 22 August 2024 Admin talk contribs uploaded File:RDT multi.jpg
18:51, 22 August 2024 Admin talk contribs created page File:RDT single.jpg
18:51, 22 August 2024 Admin talk contribs uploaded File:RDT single.jpg
10:33, 6 August 2024 Admin talk contribs created page Pan-specific Plasmodium lactate dehydrogenase (PpanLDH) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''Use of PpanLDH in diagnosis''' The pLDH assays identify enzymes of the malaria glycolytic pathway, the proteins are distinct from human forms of LDH allowing them to be identified by RDT tests. The LDH antgens a...")
10:31, 1 August 2024 Admin talk contribs created page Species-specific forms of lactate dehydrogenase (PfLDH and PvLDH) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|'''Use of PfLDH and PvLDH in diagnosis''' The pLDH assays identify enzymes of the malaria glycolytic pathway, the proteins are distinct from human forms of LDH allowing them to be identified by RDT tests. There are...")
09:06, 18 July 2024 Admin talk contribs created page Plasmodium lactate dehydrogenase (PLDH) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''Title''' TEXT 1 ---- TEXT 2")
09:06, 18 July 2024 Admin talk contribs created page Pan-Plasmodium Aldolase Antigen (Aldolase) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''Title''' TEXT 1 ---- TEXT 2")
09:05, 18 July 2024 Admin talk contribs created page Plasmodium vivax lactate dehydrogenase (PvLDH) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''Title''' TEXT 1 ---- TEXT 2")
09:05, 18 July 2024 Admin talk contribs created page Plasmodium falciparum lactate dehydrogenase (PfLDH) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''Title''' TEXT 1 ---- TEXT 2")
09:03, 18 July 2024 Admin talk contribs created page Histidine-rich protein 2 (HRP2) (Created page with "---- '''Navigation''' Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|'''How does schizont appearance change during their development?''' Schizonts formation involves successive cycles of asexual division that eventually result in the formation of multiple separate "merozoite" forms. Those...")
10:17, 9 July 2024 Admin talk contribs deleted page File:4 PF RDT neg.jpg (Deleted old revision 20240709091358!4_PF_RDT_neg.jpg: content before blanking was: "")
10:17, 9 July 2024 Admin talk contribs deleted page File:4 PF RDT neg.jpg (Deleted old revision 20240709091659!4_PF_RDT_neg.jpg: content before blanking was: "")
10:16, 9 July 2024 Admin talk contribs uploaded a new version of File:4 PF RDT neg.jpg
10:16, 9 July 2024 Admin talk contribs deleted page File:4 RDT work.jpg (Deleted old revision 20240709091556!4_RDT_work.jpg: content before blanking was: "")
10:15, 9 July 2024 Admin talk contribs uploaded a new version of File:4 RDT work.jpg
10:13, 9 July 2024 Admin talk contribs uploaded a new version of File:4 PF RDT neg.jpg
09:40, 9 July 2024 Admin talk contribs deleted page File:0 PF RDT.jpg (Deleted old revision 20240709084024!0_PF_RDT.jpg: content before blanking was: "")
09:40, 9 July 2024 Admin talk contribs uploaded a new version of File:0 PF RDT.jpg
22:50, 27 June 2024 Admin talk contribs created page File:1 PF RDT pre.jpg
22:50, 27 June 2024 Admin talk contribs uploaded File:1 PF RDT pre.jpg
22:48, 27 June 2024 Admin talk contribs deleted page File:2 PF RDT lysate.jpg (content was: "", and the only contributor was "Admin" (talk))
22:47, 27 June 2024 Admin talk contribs deleted page File:1 PF RDT pre.jpg (content before blanking was: "")
09:01, 27 June 2024 Admin talk contribs deleted page File:1 PF RDT pre.jpg (Deleted old revision 20240627080117!1_PF_RDT_pre.jpg: content before blanking was: "")
09:01, 27 June 2024 Admin talk contribs uploaded a new version of File:1 PF RDT pre.jpg
08:25, 27 June 2024 Admin talk contribs deleted page File:2 RDT work b.jpg (Deleted old revision 20240627072529!2_RDT_work_b.jpg: content before blanking was: "")
08:25, 27 June 2024 Admin talk contribs uploaded a new version of File:2 RDT work b.jpg
22:32, 26 June 2024 Admin talk contribs deleted page File:2 RDT work b.jpg (Deleted old revision 20240626213244!2_RDT_work_b.jpg: content before blanking was: "")
22:32, 26 June 2024 Admin talk contribs uploaded a new version of File:2 RDT work b.jpg
22:25, 26 June 2024 Admin talk contribs created page File:2 RDT work b.jpg

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