Prozone effect

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The prozone-like phenomenon The prozone-like phenomenon (perhaps better termed the postzone effect in this context) is a very rare, but recognised effect that causes false negative results of tests. Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.