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'''Malaria-species-specific antigens used in RDT tests'''</br></br>
'''Malaria-species-specific antigens used in RDT tests'''</br></br>
Some antigens are specifically expressed in individual malaria species and can be used to identify them as part of RDT assays. Two proteins are used for this purpose and are widely employed in RDT assays. These are::</br></br>
Some porotein antigens are expressed only by specific malaria species; these can therefore be used to identify these species as part of RDT assays. Two proteins are used for this purpose and are widely employed in RDT assays. These are::</br></br>
(1) Histidine-rich protein 2 (HRP2): An antigen that is specific for ''P.falciparum'' - [[Histidine-rich protein 2 (HRP2)|Click for details of HRP2]]</br>
(1) Histidine-rich protein 2 (HRP2): An antigen that is specific for ''P.falciparum'' - [[Histidine-rich protein 2 (HRP2)|Click for details of HRP2]]</br>
(2) Forms of lactate dehydrogenase that are specific for either ''P.falciparum'' or ''P.vivax''  [[Species-specific forms of lactate dehydrogenase (PfLDH and PvLDH)|Click for details of PfLDH or PvLDH]]</br></br>
(2) Forms of lactate dehydrogenase that are specific for either ''P.falciparum'' or ''P.vivax''  [[Species-specific forms of lactate dehydrogenase (PfLDH and PvLDH)|Click for details of PfLDH or PvLDH]]</br></br>

Revision as of 12:23, 3 October 2024

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RDT Test antigens: review of advantages and disadvantages

Malaria-species-specific antigens used in RDT tests

Some porotein antigens are expressed only by specific malaria species; these can therefore be used to identify these species as part of RDT assays. Two proteins are used for this purpose and are widely employed in RDT assays. These are::

(1) Histidine-rich protein 2 (HRP2): An antigen that is specific for P.falciparum - Click for details of HRP2
(2) Forms of lactate dehydrogenase that are specific for either P.falciparum or P.vivax Click for details of PfLDH or PvLDH

Malaria-species-specific antigens used in RDT tests

The "pan-specific antigens" react with any of the malaria species that infect humans. Those used in malaria parasites are either the form of plasmodium lactate dehydrogenase found in all species (pan-malarial LDH) or the forms of the enzyme aldolase found in all malarial species parasite aldolase:

Click for details

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