Emerging strategies and options: Difference between revisions

Revision as of 09:55, 29 September 2024

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Emerging Strategies for RDT design Multiplexed detection strategies These may be used in some circumstances to optimise performance according to local requirements: (a) Where both P.falciparum and P.vivax are highly prevalent, then tests with specificity for each species may prove valuable - P.falciparum (HRP2) and P.vivax (Pv-pLDH) may be combined with or without a pan-specific antibody. This can offer some advantages in detecting dual infection by the two species. (b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.

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 <span style="font-size:90%">'''Multiplexed detection strategies'''
-</br>These may be used in some circumstances to optimise performance according to local requirements:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
+</br>These may be used in some circumstances to optimise performance according to local requirements:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pan-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
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