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|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Emerging Strategies for RDT design'''</span>
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Emerging Strategies for RDT design'''</span>
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<span style="font-size:90%">'''Multiplexed detection strategies''' may be used in some circumstances to optimase performance for local need:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
<span style="font-size:90%">'''Multiplexed detection strategies'''  
</br>These may be used in some circumstances to optimise performance according to local requirements:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
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Revision as of 09:54, 29 September 2024


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Emerging Strategies for RDT design

Multiplexed detection strategies
These may be used in some circumstances to optimise performance according to local requirements:

(a) Where both P.falciparum and P.vivax are highly prevalent, then tests with specificity for each species may prove valuable - P.falciparum (HRP2) and P.vivax (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.

(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.