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Co-infection with two species: Difference between revisions

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{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; color:black"
|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"|<span style="color:navy>'''Practical considerations '''</span>
|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"|<span style="color:navy>'''Dual species infection'''</span>


Mixed-species malaria infections are often not recognized or underestimated. In Asia, surveys usually report that <2% of infections are mixed, whereas therapeutic studies in vivax or falciparum malaria have demonstrated a high prevalence (up to 30%) of infection with the other malaria species during convalescence, suggesting covert co-infection. In epidemiological studies, a high prevalence of cryptic mixed-malaria species infection has been detected by sensitive PCR techniques. Concurrently infecting malaria species are mutually suppressive with Plasmodium falciparum tending to dominate Plasmodium vivax, but P. vivax attenuating the severity of P. falciparum. There is evidence for some cross-species immunity. These interactions have important clinical and public health implications.
In short, mixed-species malaria infections occur, but may go unrecognised. Their precise frequency will vary according to the case-mix in the area concerned. They may only be detected during convalescence.  
 
In endemic areas where multiple malarial species circulate estimates of prevalence may be as high as 30%, but in other areas this is far lower and would often be regarded as forming fewer than 5% of infections.


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Revision as of 15:49, 26 September 2024

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Dual species infection

In short, mixed-species malaria infections occur, but may go unrecognised. Their precise frequency will vary according to the case-mix in the area concerned. They may only be detected during convalescence.

In endemic areas where multiple malarial species circulate estimates of prevalence may be as high as 30%, but in other areas this is far lower and would often be regarded as forming fewer than 5% of infections.

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