Emerging strategies and options: Difference between revisions

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Emerging Strategies Multiplexed detection strategies may be used in some circumstances to optimase performance for local need: (a) Where both P.falciparum and P.vivax are highly prevalent, then tests with specificity for each species may prove valuable - P.falciparum (HRP2) and P.vivax (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species. Where HRP2 deletion mutations pose high risk of test failure, tests can be multiplexed to select for Pf-pLDH and HRP2. This may improve detection of P.falciparum malaria.

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-<span style="font-size:90%">'''Multiplexed detection strategies may be used in some circumstances to optimase performance for local need:'''</br></br>(a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, tests may be compiled the identify each with specificity -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH). This can offer some advantages in detecting dual infection by the two species when compared to using a pan-malarial antibody.
+<span style="font-size:90%">'''Multiplexed detection strategies''' may be used in some circumstances to optimase performance for local need:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>Where HRP2 deletion mutations pose high risk of test failure, tests can be multiplexed to select for Pf-pLDH and HRP2. This may improve detection of ''P.falciparum'' malaria.
-to distinguish between infections by P. falciparum and P. vivax.
-Alternatively, tests can be multiplexed to select for Pf-pLDH and HRP2, which yields highly sensitive indications for falciparum malaria. [16] Multiplexed RDTs have also proven to be efficacious in discriminating between distinct diseases with non-specific symptomatic presentations.