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|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"|<span style="color:navy>'''Practical considerations '''</span>
|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"|<span style="color:navy>'''Emerging Strategies'''
 
 
<span style="font-size:90%">Multiplexed detection strategies may be used in some circumstances to optimase performance for local need:</br>(a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, tests may be compiled the identify each with specificity -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH). This can offer some advantages in detecting dual infection by the two species when compared to using a pan-malarial antibody.




<span style="font-size:90%">In order to improve test sensitivities when dealing with non-ideal biomarkers, manufacturers of RDTs often seek to use the multiplexed detection of distinct, species-specific antigens. In the case of malaria, RDTs are often multiplexed to detect HRP2 and the P. vivax variant of parasite lactate dehydrogenase (Pv-pLDH), to distinguish between infections by P. falciparum and P. vivax. Alternatively, tests can be multiplexed to select for Pf-pLDH and HRP2, which yields highly sensitive indications for falciparum malaria. [16] Multiplexed RDTs have also proven to be efficacious in discriminating between distinct diseases with non-specific symptomatic presentations.
to distinguish between infections by P. falciparum and P. vivax.  
Alternatively, tests can be multiplexed to select for Pf-pLDH and HRP2, which yields highly sensitive indications for falciparum malaria. [16] Multiplexed RDTs have also proven to be efficacious in discriminating between distinct diseases with non-specific symptomatic presentations.

Revision as of 14:36, 13 September 2024

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Emerging Strategies


Multiplexed detection strategies may be used in some circumstances to optimase performance for local need:
(a) Where both P.falciparum and P.vivax are highly prevalent, tests may be compiled the identify each with specificity - P.falciparum (HRP2) and P.vivax (Pv-pLDH). This can offer some advantages in detecting dual infection by the two species when compared to using a pan-malarial antibody.


to distinguish between infections by P. falciparum and P. vivax. Alternatively, tests can be multiplexed to select for Pf-pLDH and HRP2, which yields highly sensitive indications for falciparum malaria. [16] Multiplexed RDTs have also proven to be efficacious in discriminating between distinct diseases with non-specific symptomatic presentations.

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