Luke

PML::RARA – Low Risk APL

Gene	Timepoints – on treatment	Duration	Follow-up post therapy	Notes
PML::RARA	Bone marrow MRD – post each cycle of treatment	Stop performing MRD once CRMRD		Recommended by both ELN and Dillon et al

PML::RARA – High Risk APL

Gene	Timepoints – on treatment	Duration	Follow-up post therapy	Notes
PML::RARA	Bone marrow MRD – post each cycle of treatment		BM MRD every 3 months for 2–3 years	Recommended by both ELN and Dillon et al ELN recommend 2 years

NPM1

Gene	Timepoints – on treatment	Additional tests	Follow-up post therapy	Notes
NPM1	Bone marrow MRD – post each cycle of treatment	PB MRD sample post cycle 2	BM 3 monthly for 2 years PB 2 monthly for 2 years	Post #2 PB sample based on AML 17 and Dillon et al *Recommendations based on Dillon et al. ELN recommends PB monitoring 4–6 weekly