Prozone effect: Difference between revisions

Revision as of 14:32, 23 August 2024

The prozone effect is a very rare, but recognised effect that causes false negative results of tests. Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess antigen). The presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented causing the test to appear negative. Return to HRP2 page

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-The prozone effect is a very rare, but recognised effect, most often this affects HRP2 antigens and means that in very high parasitaemia (causing excess antigen). The presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented causing the test to appear negative.
+The prozone effect is a very rare, but recognised effect that causes false negative results of tests.
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+Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess antigen). The presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented causing the test to appear negative.
 [[Histidine-rich protein 2 (HRP2)|Return to HRP2 page]]