Biology Quiz A Q1

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Malaria Biology Quiz A Q1 Following a mosquito bite the newly introduced malarial parasite will first enter the liver cells and replicate - only after this do they enter blood. In some species parasites may remain dormant in this liver stage (as a "hypnozoite") before re-emerging to cause a late or recurrent infection after weeks, months or perhaps longer. In which species can late infection emerge from dormant parasites in liver?? Make one or more selections P.falciparum P.vivax P.ovale P.malariae P.knowlesi Explanation of correct answer (click "Expand"). Short answer taken from section "Main RDT page" (see the section for full details and links). The different malaria species are detected with different sensitivity. The table below provides an overall summary of the sensitivity that can be expected for RDT tests (the specific section in the main section provides more detail). P.falciparum At high parasitaemia expect high sensitivity (90-95%). This declines when parasite levels are lower (45-70%) P.vivax Expect moderate to high sensitivity at high parasitaemia (70-90%). This declines markedly when parasite levels are lower (30-60%) P.ovale & P.malarae Generally sensitivity is poor (approximately half the sensitivity shown for P.vivax) P.knowlesi Reports suggest variable sensitivity that may depend on test used, RDTs are reported tp detect this species well when parasitaemia is high. Go to next question (2 of 5)