Prozone effect: Difference between revisions
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<span style="font-size:90%">Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.</br></br>*''Note'' the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen.</span> | <span style="font-size:90%">Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.</br></br>*'''Note''' the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen.</span> | ||
Revision as of 15:23, 21 November 2024
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Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. |