HRP2 gene deletion: Difference between revisions
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'''Navigation'''</br> | |||
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br> | |||
<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br> | |||
<span style="font-size:90%">>>[[Interpretation guide: MULTI BAND tests|Multi Band Tests]]''</span></br> | |||
<span style="font-size:90%">>>>Current page: '''Clearance of parasite antigens from blood'''</span> | |||
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|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>''' ''HRP2 gene'' deletion'''</span> | |||
<span style="font-size:90%">Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing.</span> | <span style="font-size:90%">Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing.</span> | ||
Revision as of 14:06, 30 October 2024
Navigation
Main Malaria Index
>RDT main page
>>Single Band Tests
>>>Current page: HRP2 gene deletion
Navigation
Main Malaria Index
>RDT main page
>>Multi Band Tests
>>>Current page: Clearance of parasite antigens from blood
| HRP2 gene deletion
Gene-deletion mutations affecting HRP2 and HRP3 genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing. (1) Deletions of HRP2 prevent its synthesis, causing reduced sensitivity (or sometimes entirely negative test results). In the presence of high parasitaemia HRP2 tests may still work even in the presence of single gene deletions of HRP2 since the test also detects HRP3 protein. (2) Note also the dual gene-deletions affecting both HRP2 and HRP3 genes are now recognised, and these cause fully negative test results.
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