Prozone effect: Difference between revisions
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|colspan="1" style = "font-size:110%; color:blasck; background: FFFAFA"|<span style="color:navy>'''The prozone-like phenomenon'''</span> | |colspan="1" style = "font-size:110%; color:blasck; background: FFFAFA"|<span style="color:navy>'''The prozone-like (postzone) phenomenon'''</span> | ||
The prozone-like phenomenon ( | The prozone-like or "postzone" phenomenon (the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen) is a very rare, but recognised effect that causes false negative results of tests. | ||
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Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. | Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. | ||
Revision as of 10:27, 9 October 2024
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| The prozone-like (postzone) phenomenon
Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. |