RDT test: formats of tests: Difference between revisions
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<span style="font-size:90%">This test format usually uses the HRP2 antigen (or | <span style="font-size:90%">This test format usually uses the HRP2 antigen (or Pf-LDH) to detect infection by ''P.falciparum''. The format offers particular advantages:</span> | ||
*<span style="font-size:90%">Simple interpretation | *<span style="font-size:90%">Simple interpretation | ||
*<span style="font-size:90%">lower production cost | *<span style="font-size:90%">lower production cost | ||
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<span style="font-size:90%">Most often one band is a species-specific antibody that identifies the dominant (or most important) species for the selected region (generally''P.falciparum'' but in saome areas ''P.vivax''. The second band is most often a pan-malaria antibody.</br></br> | <span style="font-size:90%">Most often one band is a species-specific antibody that identifies the dominant (or most important) species for the selected region (generally''P.falciparum'' but in saome areas ''P.vivax''. The second band is most often a pan-malaria antibody.</br></br> | ||
The format offers advantages: | *<span style="font-size:90%">The format offers advantages:</span> | ||
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Second species infection | *<span style="font-size:90%">Second species infection | ||
Failure of band 1 | *<span style="font-size:90%">Failure of band 1 | ||
However, the limitations must be understood by users. In particular the poor sensitivity of pan-malarial antibodies for some species. | *<span style="font-size:90%">However, the limitations must be understood by users. In particular the poor sensitivity of pan-malarial antibodies for some species. | ||
[[less common strategies]] | [[less common strategies]] | ||
Revision as of 15:52, 24 September 2024
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| TEST FORMATS |
Single test-band RDT tests
This test format usually uses the HRP2 antigen (or Pf-LDH) to detect infection by P.falciparum. The format offers particular advantages:
- Simple interpretation
- lower production cost
- Stability (of HRP2) for storage and transport
Use: The single band test detecting only P.falciparum is very useful in Africa, since in many areas infections with this species account for more than 95% of malarial infection. The test is very useful in more remote areas where technical expertise in microscopy and interprtation is often less available. However, this is at the cost missing less prevelant species, and where [ HRP2-gene deletion ] is frequent infection may be missed.
Multi-band RDT tests
These use two (or occasionally more) test bands together with a control band.
Most often one band is a species-specific antibody that identifies the dominant (or most important) species for the selected region (generallyP.falciparum but in saome areas P.vivax. The second band is most often a pan-malaria antibody.
- The format offers advantages:
- Second species infection
- Failure of band 1
- However, the limitations must be understood by users. In particular the poor sensitivity of pan-malarial antibodies for some species.