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General and specific limitations of RDT tests: Difference between revisions

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|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"|<span style="color:navy>'''Practical considerations '''</span>
|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"|<span style="color:navy>'''Practical considerations '''</span>


In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards, sufficiently low limits of detection have not been demonstrated for the early and accurate diagnosis of nascent infections, or of asymptomatic carriers.
RDT evaluationby WHO requires tests to identify 75% of cases there are 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.

Revision as of 14:25, 13 September 2024

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Practical considerations

RDT evaluationby WHO requires tests to identify 75% of cases there are 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of P.falciparum using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.

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