Prozone effect: Difference between revisions

Revision as of 16:07, 6 October 2024

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The prozone effect is a very rare, but recognised effect that causes false negative results of tests. Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.

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+'''Navigation'''</br>
+<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br>
+<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
+<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br>
+<span style="font-size:90%">>>>Current page: '''The prozone effect'''</span>
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 Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.
-[[Histidine-rich protein 2 (HRP2)|Return to HRP2 page]]