Prozone effect: Difference between revisions

Revision as of 21:02, 28 August 2024

The prozone effect is a very rare, but recognised effect that causes false negative results of tests. Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. Return to HRP2 page

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-Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess antigen). The presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented causing the test to appear negative.
+Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.
 [[Histidine-rich protein 2 (HRP2)|Return to HRP2 page]]