Pan-specific Plasmodium lactate dehydrogenase (PpanLDH): Difference between revisions
From MalariaETC
(Created page with "---- '''Navigation'''</br> Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|<span style="color:navy>'''Use of PpanLDH in diagnosis'''</span> The pLDH assays identify enzymes of the malaria glycolytic pathway, the proteins are distinct from human forms of LDH allowing them to be identified by RDT tests. The LDH antgens a...") |
No edit summary |
||
| Line 11: | Line 11: | ||
The pLDH assays identify enzymes of the malaria glycolytic pathway, the proteins are distinct from human forms of LDH allowing them to be identified by RDT tests. The LDH antgens are relatively rapidly cleared from the blood, so have value in testing response to treatment or for malaria testing in recently infected patients.There are species-specific forms of LDH (see separate description). | The pLDH assays identify enzymes of the malaria glycolytic pathway, the proteins are distinct from human forms of LDH allowing them to be identified by RDT tests. The LDH antgens are relatively rapidly cleared from the blood, so have value in testing response to treatment or for malaria testing in recently infected patients.There are species-specific forms of LDH (see separate description). | ||
'''The non-species-specific form (PpanLDH)''' is most widely used in combination with a species-specific antigen: most often recognising ''P.falciparum'', although in some geographical areas this is a form that recognises ''P.vivax''. Choice depends very much on local prevalance. | '''The non-species-specific form (PpanLDH)''' is most widely used in combination with a species-specific antigen: most often recognising ''P.falciparum'', although in some geographical areas this is a form that recognises ''P.vivax''. Choice depends very much on local prevalance. | ||
PF dominant but concern of resistance | '''For example:''' | ||
PF dominant but other species frequently encountered | |||
PV dominant but PF possible | *PF dominant but concern of resistance | ||
*PF dominant but other species frequently encountered | |||
*PV dominant but PF possible | |||
---- | ---- | ||
<span style="color:navy>'''Characteristics of pan-specific forms of LDH'''</span> | <span style="color:navy>'''Characteristics of pan-specific forms of LDH'''</span> | ||
Not a general malaria test as has poor sensitivity for some species, expect: | |||
Revision as of 10:34, 6 August 2024
Navigation
Go Back
| Use of PpanLDH in diagnosis
The non-species-specific form (PpanLDH) is most widely used in combination with a species-specific antigen: most often recognising P.falciparum, although in some geographical areas this is a form that recognises P.vivax. Choice depends very much on local prevalance. For example:
Not a general malaria test as has poor sensitivity for some species, expect: |