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RDT Quiz A Q2: Difference between revisions

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! colspan="1" | Explanation of correct answer (click "Expand")
! colspan="1" | Explanation of correct answer (click "Expand")
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|</b><span style="font-size:90%">The different malaria species are detected with different sensitivity. The table below provides an overall summary of the sensitivity that can be expected for RDT tests when suitable species-specific together with pan-malarial antibodies are used. The table is only a broad summary. </span></br></br>
|{| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"
|colspan="1" style = "font-size:100%; color:black; background: gainsboro |'''RESULT PATTERN 1'''
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<span style="font-size:90%; color:maroon">These are '''invalid tests''' No band appears in the control area (black arrow)</span>: </br></br>


<div style="width:100%; font-size:90%;">
<gallery mode="nolines" widths=80px heights=160px>
{| class="wikitable" style="border-style: solid; border-width: 4px; color:black; font-size:90%;"
File:RDT_multi_fail1.jpg|<span style="font-size:90%"></span>|link={{filepath:RDT_multi_fail1.jpg}}
!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%">''' ''P.falciparum<sup>1</sup> '''</br>
File:RDT_multi_fail2.jpg|<span style="font-size:90%"></span>|link={{filepath:RDT_multi_fail1.jpg}}
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File:RDT_multi_fail3.jpg|<span style="font-size:90%"></span>|link={{filepath:RDT_multi_fail1.jpg}}
!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">At high parasitaemia expect high sensitivity (90-95%). This declines when parasite levels are lower (45-70%)<sup>2</sup>
File:RDT_multi_fail4.jpg|<span style="font-size:90%"></span>|link={{filepath:RDT_multi_fail1.jpg}}
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</gallery>
!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%;">''' ''P.vivax'' '''</span></br>
<span style="font-size:90%">Irrespective of whether any other bands are present, this is always an invalid test: '''do not interpret.''' Report as failed test</br>Action:</span>  
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*<span style="font-size:90%">Repeat the test</br></span>
!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">Expect moderate to high sensitivity at high parasitaemia (70-90%). This declines markedly when parasite levels are lower (30-60%)<sup>2</sup>
*<span style="font-size:90%">Consider the reasons for [ [[Practical reasons for test failure|test failure]] ]</span>
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!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%;">''' ''P.ovale & P.malarae'' '''</span></br>
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!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">Generally sensitivity is poor (approximately half the sensitivity shown for ''P.vivax'')
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!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%;">''' ''P.knowlesi''<sup>3</sup> '''</span></br>
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!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">Reports suggest variable sensitivity that may depend on test used, RDTs are reported tp detect this species well when parasitaemia is high.
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<span style="font-size:80%">Notes:</br></span>
<span style="font-size:80%"><sup>1</sup> HRP2 mutation mean that in some geographical areas the diagnostic sensitivity may be significantly lower for HRP2-based tests (see below)</br></span>
<span style="font-size:80%"><sup>2</sup> Low parasite number is considered as (<1000 parasites/μL) a level that may cause symptoms in children or non-immune travellers</br></span>
<span style="font-size:80%"><sup>3</sup> There have been relatively few studies with this species so caution is required in RDT interpretation</br></span>
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</br>
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{| class="wikitable" style="width:300px; border-left:solid 4px navy;border-right:solid 4px navy;border-top:solid 4px navy;border-bottom:solid 4px navy; font-size:100%; color:navy; align:center"
{| class="wikitable" style="width:300px; border-left:solid 4px navy;border-right:solid 4px navy;border-top:solid 4px navy;border-bottom:solid 4px navy; font-size:100%; color:navy; align:center"
|colspan="1" style = "font-size:90%; color:black|<span style="color:black>[[RDT_Quiz_A_Q3|Go to next question (3 of 5)]]</span>
|colspan="1" style = "font-size:90%; color:black|<span style="color:black>[[RDT_Quiz_A_Q3|Go to next question (3 of 5)]]</span>

Revision as of 18:47, 23 November 2024

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RDT Quiz A

1. This is an RDT test using a pan-malarial antibody (pan) and a P.falciparum? spsecific antibody (Sp). What is the most likely interpretion?

Consistent with a single species P.falciparum infection
Consistent with a single species non-P.falciparum infection
Most consistent with a dual species infection including P.falciparum
Most consistent with a dual species infection not including P.falciparum
Most consistent with a dual species infection not including P.falciparum
An unreportable test


Explanation of correct answer (click "Expand")
class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black" RESULT PATTERN 1

These are invalid tests No band appears in the control area (black arrow):

Irrespective of whether any other bands are present, this is always an invalid test: do not interpret. Report as failed test
Action:


Go to next question (3 of 5)
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