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| |colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''How well do RDT tests detect the different malaria species?'''</span>
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| </b><span style="font-size:90%">The different malaria species are detected with different sensitivity. The table below provides an overall summary of the sensitivity that can be expected for RDT tests when suitable species-specific together with pan-malarial antibodies are used. The table is only a broad summary. Users are advised to understand the characteristics of the test they use including the merits of the antibodies employed in their test (see section below) </span></br></br>
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| !colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%">''' ''P.falciparum<sup>1</sup> '''</br>
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| !colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">At high parasitaemia expect high sensitivity (90-95%). This declines when parasite levels are lower (45-70%)<sup>2</sup>
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| !colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%;">''' ''P.vivax'' '''</span></br>
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| !colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">Expect moderate to high sensitivity at high parasitaemia (70-90%). This declines markedly when parasite levels are lower (30-60%)<sup>2</sup>
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| !colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%;">''' ''P.ovale & P.malarae'' '''</span></br>
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| !colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">Generally sensitivity is poor (approximately half the sensitivity shown for ''P.vivax'')
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| !colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|<span style="font-size:90%;">''' ''P.knowlesi''<sup>3</sup> '''</span></br>
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| !colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|<span style="font-size:90%">Reports suggest variable sensitivity that may depend on test used, RDTs are reported tp detect this species well when parasitaemia is high.
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| </div>
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| <span style="font-size:80%">Notes:</br></span>
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| <span style="font-size:80%"><sup>1</sup> HRP2 mutation mean that in some geographical areas the diagnostic sensitivity may be significantly lower for HRP2-based tests (see below)</br></span>
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| <span style="font-size:80%"><sup>2</sup> Low parasite number is considered as (<1000 parasites/μL) a level that may cause symptoms in children or non-immune travellers</br></span>
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| <span style="font-size:80%"><sup>3</sup> There have been relatively few studies with this species so caution is required in RDT interpretation</br></span>
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| </br>
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| |}
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| [[RDT_MCQ_A1|Explanation of answer]] | | [[RDT_MCQ_A1|Explanation of answer]] |