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Co-infection with two species: Difference between revisions

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(Created page with "Mixed-species malaria infections are often not recognized or underestimated. In Asia, surveys usually report that <2% of infections are mixed, whereas therapeutic studies in vivax or falciparum malaria have demonstrated a high prevalence (up to 30%) of infection with the other malaria species during convalescence, suggesting covert co-infection. In epidemiological studies, a high prevalence of cryptic mixed-malaria species infection has been detected by sensitive PCR tec...")
 
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Mixed-species malaria infections are often not recognized or underestimated. In Asia, surveys usually report that <2% of infections are mixed, whereas therapeutic studies in vivax or falciparum malaria have demonstrated a high prevalence (up to 30%) of infection with the other malaria species during convalescence, suggesting covert co-infection. In epidemiological studies, a high prevalence of cryptic mixed-malaria species infection has been detected by sensitive PCR techniques. Concurrently infecting malaria species are mutually suppressive with Plasmodium falciparum tending to dominate Plasmodium vivax, but P. vivax attenuating the severity of P. falciparum. There is evidence for some cross-species immunity. These interactions have important clinical and public health implications.
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'''Navigation'''</br>
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br>
<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br>
<span style="font-size:90%">>>>Current page: '''Co-infection with two species'''</span>
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{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal"
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Dual species infection'''</span>
 
 
<span style="font-size:90%">Mixed-species malaria infections certainly occur. Their precise frequency will vary according to the case-mix in the area concerned.</br></br>In endemic areas where multiple malarial species circulate estimates of prevalence may be as high as 30%, but in other areas this is far lower and would often be regarded as forming fewer than 5% of infections.</span>
 
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<span style="font-size:90%">Recogition by morphology requires the presence of parasite forms that have recognisable species-specific features for two separate species. This may sometimes be easy, but can be challenging when one species predominates. Some examples are shown below:</br></br></span>
 
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File:Dual1.jpg|<span style="font-size:90%"></span>|A|link={{filepath:Dual1.jpg}}
File:Dual2.jpg|<span style="font-size:90%"></span>|B|link={{filepath:Dual2.jpg}}
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<span style="font-size:90%">'''Image A''': two gametocytes in separate red cells. These clearly have different appearances - one has the elongated and curved form typical of ''P.falciparum'', while the second is "round" with visible round bametocytecytoplasmic dots and fimbriation of the red cell - appearances of ''P.ovale''.</br<</br>'''Image B''': a large parasite within the red cell is clearly seen and has the chacteristics of a microgametocyte of ''P.ovale'', but note also a small fine early "double dot" ring form  of ''P.falciparum'' that is within the same erythocyte - an unusual "dual-parasite" erythrocyte!</span>

Latest revision as of 13:30, 21 November 2024


Navigation
Main Malaria Index
>RDT main page
>>Single Band Tests
>>>Current page: Co-infection with two species


Dual species infection


Mixed-species malaria infections certainly occur. Their precise frequency will vary according to the case-mix in the area concerned.

In endemic areas where multiple malarial species circulate estimates of prevalence may be as high as 30%, but in other areas this is far lower and would often be regarded as forming fewer than 5% of infections.


Recogition by morphology requires the presence of parasite forms that have recognisable species-specific features for two separate species. This may sometimes be easy, but can be challenging when one species predominates. Some examples are shown below:

Image A: two gametocytes in separate red cells. These clearly have different appearances - one has the elongated and curved form typical of P.falciparum, while the second is "round" with visible round bametocytecytoplasmic dots and fimbriation of the red cell - appearances of P.ovale.</br<
Image B: a large parasite within the red cell is clearly seen and has the chacteristics of a microgametocyte of P.ovale, but note also a small fine early "double dot" ring form of P.falciparum that is within the same erythocyte - an unusual "dual-parasite" erythrocyte!