Actions

General and specific limitations of RDT tests: Difference between revisions

From MalariaETC

(Created page with "In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards,...")
 
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards, sufficiently low limits of detection have not been demonstrated for the early and accurate diagnosis of nascent infections, or of asymptomatic carriers.
{{DISPLAYTITLE:<span style="position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);">{{FULLPAGENAME}}</span>}}
----
'''Navigation'''</br>
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br>
<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br>
<span style="font-size:90%">>>>Current page: '''Detection limites of RDT tests'''</span>
----
 
 
{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; color:black"
|colspan="1" style = "font-size:110%; color:blasck; background: FFFAFA"|<span style="color:navy>'''Detection limits of RDTs'''</span>
 
 
<span style="font-size:90%">RDT evaluationby WHO requires tests to identify 75% of cases at parasite concentration of 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.</br></br>These limitations are also summarised in the Table on the main page.</span>
 
----

Latest revision as of 14:01, 21 November 2024

Navigation
Main Malaria Index
 >RDT main page
 >>Single Band Tests
 >>>Current page: Detection limites of RDT tests


Detection limits of RDTs


RDT evaluationby WHO requires tests to identify 75% of cases at parasite concentration of 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of P.falciparum using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.

These limitations are also summarised in the Table on the main page.

Retrieved from "https://haematologyetc.org/index.php?title=General_and_specific_limitations_of_RDT_tests&oldid=1253"