Prozone effect: Difference between revisions
From MalariaETC
No edit summary |
No edit summary |
||
| (15 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{DISPLAYTITLE:<span style="position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);">{{FULLPAGENAME}}</span>}} | |||
---- | |||
'''Navigation'''</br> | |||
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br> | |||
<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br> | |||
<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br> | |||
<span style="font-size:90%">>>>Current page: '''The prozone-like effect'''</span> | |||
---- | |||
{| class="wikitable" style="border-style: solid; border-width: 4px; border-color:green" | {| class="wikitable" style="border-style: solid; border-width: 4px; border-color:green" | ||
|colspan="1" style = "font-size:110%; color: | |colspan="1" style = "font-size:110%; color:blasck; background: FFFAFA"|<span style="color:navy>'''The prozone-like (postzone) phenomenon'''</span> | ||
<span style="font-size:90%">Moew correctly the "prozone-like" or "postzone" phenomenon* is a very rare, but recognised effect that causes false negative results of tests. | |||
---- | |||
<span style="font-size:90%">Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.</br></br>*'''Note''' the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen as in this case.</span> | |||
Latest revision as of 15:25, 21 November 2024
Navigation
Main Malaria Index
>RDT main page
>>Single Band Tests
>>>Current page: The prozone-like effect
| The prozone-like (postzone) phenomenon
Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. |