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Central chromatin dot 1: Difference between revisions

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<span style="font-size:90%">The dots of different species represent parasite proteins that modify red cell function in a range of ways to support parasite development, immun evasion or virulence. Their precise functions are ill defined, but their appearances have value in distinguishing the different species of parasite. The dots require a well-stained specimen to be easily seen!</span>
<span style="font-size:90%">Early or late trophozoites in which the chromatin dot lies within the central vacuole of the parasite are observed with higher frequency in ''P.malariae'' than with other species, and though not fully characteristic of the species they contribute to diagnosis if other features ae consistent.</span>
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<span style="font-size:90%>'''Schüffner's dots''' (P.vivax) and '''James' dots)''' (''P.ovale'') become apparent during the early trophzoite as faint dots then to be easily seen in later stages. These two forms of dots are morphologically indistinguishable as frequent evenly-distrubuted round dots od similar size.</span>
<gallery mode="nolines" widths="220px" heights="220px" >
<gallery mode="nolines" widths="220px" heights="220px" >
File:Schuffner_dots.jpg|link={{filepath:Schuffner_dots.jpg}}
File:PMcentral.jpg|link={{filepath:PMcentral.jpg}}
</gallery>
</gallery>
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<span style="font-size:90%>Central chromatin dot may also be seen in cells infected by other species; shown for ''P.falciparum'', ''P.ovale'' (note the James' dots), or ''P.vivax'' (with prominent Schüffner's dots and visible pigment).
<gallery mode="nolines" widths="220px" heights="220px" >
File:PFcentral.jpg|''P.falciparum''|link={{filepath:PFcentral.jpg}}
File:POcentral.jpg|''P.ovale''|link={{filepath:POcentral.jpg}}
File:PVcentral.jpg|''P.vivax''|link={{filepath:PVcentral.jpg}}
</gallery>

Latest revision as of 13:27, 22 December 2024

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Central chromatin dot form

Early or late trophozoites in which the chromatin dot lies within the central vacuole of the parasite are observed with higher frequency in P.malariae than with other species, and though not fully characteristic of the species they contribute to diagnosis if other features ae consistent.

Central chromatin dot may also be seen in cells infected by other species; shown for P.falciparum, P.ovale (note the James' dots), or P.vivax (with prominent Schüffner's dots and visible pigment).

  • P.falciparum

    P.falciparum

  • P.ovale

    P.ovale

  • P.vivax

    P.vivax

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