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Plasmodium malariae: Morphology: Difference between revisions

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<span style="font-size:120%; color:black">'''Morphology of ''Plasmodium malariae'' '''</br></span><span style="font-size:90%; color:black">(see Malaria Biology pages for an explanation of these stages)</span>
<span style="font-size:120%; color:black">''' ''Plasmodium malariae'' '''</br></span>
</br></br><span style="font-size:90%">'''Geographical distribution:''' ''P. malariae'' infection overlaps that of ''P.falciparum'' in areas that include sub-Saharan Africa, Southeast Asia, Indonesia, the western Pacific and in areas of the Amazon Basin of South America.</span>
<span style="font-size:90%">''P. malariae'' infection overlaps geographically with the distribution of ''P.falciparum'' in areas that include sub-Saharan Africa, Southeast Asia, Indonesia, the western Pacific and in areas of the Amazon Basin of South America.</span>
 
 
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</br>
</br><span style="font-size:120%">The early trophozoite</span></br>
</br><span style="font-size:100%">'''The early trophozoite'''</span></br>
<gallery mode="nolines" widths=250px heights=250px>
<gallery mode="nolines" widths=220px heights=220px>
File:PMETc.jpg|link={{filepath:PMETc.jpg}}
File:PMETanno.jpg|link={{filepath:PMETc.jpg}}
File:MET1g.jpg|link={{filepath:MET1g.jpg}}
File:MET1g.jpg|link={{filepath:MET1g.jpg}}
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<span style="font-size:90%">During this later growth stage the rings enlarge and begin to modify the erythrocyte, forming typical features of the species.</span>
<span style="font-size:90%">During this later growth stage the rings enlarge and begin to modify the erythrocyte, forming typical features of the species.</span>
*Small but well-formed rings are typically seen someimes with a [[central chromatin dot]] or elongation
*<span style="font-size:90%">Small but well-formed rings are typically seen sometimes with a [[Central_chromatin_dot_1|central chromatin dot]] or elongation
*Red cells are generally of normal size, though occasionally may have reduced volume
*<span style="font-size:90%">Red cells are generally of normal size, though occasionally may have reduced volume
*Pigment will not generally be present at this developmental stage
*<span style="font-size:90%">Pigment will not generally be present at this developmental stage
</br>
</br>
<div style="width: 350px">
'''GALLERY:'''
{| class="wikitable" style="border-left:solid 4px navy;border-right:solid 4px navy;border-top:solid 4px navy;border-bottom:solid 4px navy; font-size:110%; color:navy; align:center"
[[P.malariae early trophozoites gallery|''P.malariae'' early trophozoites]]
| colspan="1"''|[[P.malariae early trophozoites gallery|GALLERY]]''
|}
</div>
 
 
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</br><span style="font-size:110%">'''The late trophozoite'''</span>
</br><span style="font-size:130%">The late trophozoite</span>
</br>
<gallery mode="nolines" widths=250px heights=250px>
<gallery mode="nolines" widths=220px heights=220px>
File:PMLTc.jpg|link={{filepath:PMLTc.jpg}}
File:PMLTanno.jpg|link={{filepath:PMLTc.jpg}}
File:PMLT2.jpg|link={{filepath:PMLT2.jpg}}
File:PMLT2.jpg|link={{filepath:PMLT2.jpg}}
</gallery>
</gallery>
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<span style="font-size:90%">Text</span>
<span style="font-size:90%">In this species the parasite form changes significantly as the mature, characteristically elongating or becoming more angular, red cells may often appear smaller though not distorted.</span>
*Parasites are larger and may be elongated, sometimes forming a [[band]] across the infected red cell
*<span style="font-size:90%">Parasites may be elongated, forming a [[Band_form_PM|band]] across the infected red cell
*Red cells remain round, but [[size is often reduced]]
*<span style="font-size:90%">Others spread to form an [[Anglular_form_PM|angular or basket form]] within the red cell
*cytoplasmic dots are uncommon but [[may be seen]]
*<span style="font-size:90%">Red cells remain round, but [[Size_and_shape_PM|red cell size is often reduced]]
*[[Pigment]] can now be seen over the parasite surface
*<span style="font-size:90%">cytoplasmic dots are uncommon but [[Added_dots_PM|Ziemann's stippling]] may be seen
*<span style="font-size:90%">Pigment can now be seen over the parasite surface
</br>
</br>
<div style="width: 350px">
<div style="width: 350px">
{| class="wikitable" style="border-left:solid 4px navy;border-right:solid 4px navy;border-top:solid 4px navy;border-bottom:solid 4px navy; font-size:110%; color:navy; align:center"
'''GALLERY:'''
| colspan="1"''|[[P.malariae late trophozoites gallery|GALLERY]]''
[[P.malariae late trophozoites gallery|''P.malariae'' late trophozoites]]
|}
</div>
</div>
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</br><span style="font-size:130%">The schizont</span></br>
</br><span style="font-size:110%">'''The schizont'''</span></br>
<gallery mode="nolines" widths=250px heights=250px>
<gallery mode="nolines" widths=220px heights=220px>
File:PMSc.jpg|link={{filepath:PMSc.jpg}}
File:PMSanno.jpg|link={{filepath:PMSc.jpg}}
File:PMS2.jpg|link={{filepath:PMS2.jpg}}
File:PMS2.jpg|link={{filepath:PMS2.jpg}}
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<span style="font-size:90%">The asexual schizont stage of development will often be identified in the blood of this species, while smaller than ''P.vivax'', species-specific features may not be clearly seen.</span>
<span style="font-size:90%">Often present in the blood, these small schizont forms may have species-specific features.</span>
*<span style="font-size:90%">A range of [[Schizont_development_2|"schizont forms"]] will generally be present within moderately enlarged red cells
*<span style="font-size:90%">These are often seen in this species – the number of individual merozoites is often low (around 8)
*<span style="font-size:90%">When mature schizonts may contain 16-24 separate merozoites  
*<span style="font-size:90%">The central area of clumped [[Pigment_distribution_PM|pigment]] may have merozoites arranged to form a [[“daisy head” appearance]]
*<span style="font-size:90%">[[Added dots 2|James' dots]] may be detected in any residual cytoplasm of the erythrocyte
*<span style="font-size:90%">At this stage the erythrocyte is devoid of haemoglobin and the small size is readily detected
*<span style="font-size:90%">[[Malaria_pigment_2|Pigment]] will be visible in irregularly distributed clumps
</br>
</br>
<div style="width: 350px">
'''GALLERY:'''
{| class="wikitable" style="border-left:solid 4px navy;border-right:solid 4px navy;border-top:solid 4px navy;border-bottom:solid 4px navy; font-size:110%; color:navy; align:center"
[[P.malariae schizont gallery|''P.malariae'' schizonts]]
| colspan="1"''|[[P.malariae schizont gallery|GALLERY]]''
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</div>
 


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</br><span style="font-size:130%">The gametocyte</span></br>
</br><span style="font-size:110%">'''The gametocyte'''</span></br>
<gallery mode="nolines" widths=250px heights=250px>
<gallery mode="nolines" widths=220px heights=220px>
File:PMGc.jpg|link={{filepath:PMGc.jpg}}
File:PMGanno.jpg|link={{filepath:PMGc.jpg}}
File:PMG2.jpg|link={{filepath:PMG2.jpg}}
File:PMG2.jpg|link={{filepath:PMG2.jpg}}
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<span style="font-size:90%">The sexual replication form resembles ''P.vivax'' although generally smaller with sme species-specific forms detectable.
<span style="font-size:90%">The sexual replication form in this species tend to be small, neat, and round.
</br>
</br>
*<span style="font-size:90%">Red cells will generally enlarged and may have ovoid or fimbriated form
*<span style="font-size:90%">Gametocytes tend to be regular and round in shape.
*<span style="font-size:90%">[[Macro&micro_gametocytes_PO|Macrogametocytes]] (female form) will often entirely fill the erythrocyte  
*<span style="font-size:90%">The parasites are small and do not generally fill the erythrocyte
*<span style="font-size:90%">[[Macro&micro_gametocytes_PO|Microgametocytes]] (male form) have a cytoplasmic rim with visible [[Added dots 2|James' dots]]
*<span style="font-size:90%">Haemoglobin is absent and scattered pigment overlies or surrounds the gametocyte  
*<span style="font-size:90%">[[Malaria_pigment_2|Pigment]] is clumped evenly over the surface of the gametocyte
</br>
</br>
<div style="width: 350px">
'''GALLERY:'''
{| class="wikitable" style="border-left:solid 4px navy;border-right:solid 4px navy;border-top:solid 4px navy;border-bottom:solid 4px navy; font-size:110%; color:navy; align:center"
[[P.malariae gametocyte gallery|''P.malariae'' gametocytes]]
| colspan="1"''|[[P.malariae gametocyte gallery|GALLERY]]''
|}
</div>
 
 
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*Parasites tend to be small, although less fine than for P.falciparum, the number of parasites in the blood is often low.
*Infected blood tends to include all the developmental stages, some of which have features that particularly define the species
*Red cell are rarely enlarged, and most frequently have reduced size – this is a fairly useful indication of the the presence of P.malariae
*In normally stained samples there will not be added dots or clefts, although in very heavily stained samples these may be detected (name).
 
 
 
 
 
 
 
 
 
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'''Schizonts'''
 
*These are often seen in this species – the number of individual merozoites is often low (around 8)
*Mature schizonts may have a characteristic central area of clumped pigment with the merozoites arranged around this forming a “daisy head”
*At this stage the erythrocyte is devoid of haemoglobin and the small size is readily detected
 
 
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'''Gametocytes'''
 
*Gametocytes tend to be regular and round in shape.
*The parasites are small and do not generally fill the erythrocyte
*Haemoglobin is absent and pigment overlies the gametocyte 
 


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Latest revision as of 18:03, 6 February 2025

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Plasmodium malariae
P. malariae infection overlaps geographically with the distribution of P.falciparum in areas that include sub-Saharan Africa, Southeast Asia, Indonesia, the western Pacific and in areas of the Amazon Basin of South America.




The early trophozoite


During this later growth stage the rings enlarge and begin to modify the erythrocyte, forming typical features of the species.

  • Small but well-formed rings are typically seen sometimes with a central chromatin dot or elongation
  • Red cells are generally of normal size, though occasionally may have reduced volume
  • Pigment will not generally be present at this developmental stage


GALLERY: P.malariae early trophozoites



The late trophozoite


In this species the parasite form changes significantly as the mature, characteristically elongating or becoming more angular, red cells may often appear smaller though not distorted.




The schizont


Often present in the blood, these small schizont forms may have species-specific features.

  • These are often seen in this species – the number of individual merozoites is often low (around 8)
  • The central area of clumped pigment may have merozoites arranged to form a “daisy head” appearance
  • At this stage the erythrocyte is devoid of haemoglobin and the small size is readily detected


GALLERY: P.malariae schizonts




The gametocyte


The sexual replication form in this species tend to be small, neat, and round.

  • Gametocytes tend to be regular and round in shape.
  • The parasites are small and do not generally fill the erythrocyte
  • Haemoglobin is absent and scattered pigment overlies or surrounds the gametocyte


GALLERY: P.malariae gametocytes