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Plasmodium falciparum lactate dehydrogenase (PfLDH): Difference between revisions

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|colspan="1" style = "font-size:110%; color:black; background: FFFAFA"|<span style="color:navy>'''Use of PfLDH in diagnosis'''</span>
The pLDH assays identify enzymes specific to the malaria glycolytic pathway, three forms of test antigen exist: a PpanLDH which has capability to detect all forms of malaria (see separate description) and "species specific" forms that detect forms found only in particular malaria forms: a ''P.falciparum''-specific form (PfLDH) and a ''P.vavax''-specific form (PvLDH).
The PfLDH has excellent sensitivity at high parasitaemia, with sensitivity that may meet or exceed 90%. However, at lower parasite levels (<1000 parasites/ μL) sensitivity of PfLDH may be lower than HRP2 (around 45%).
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<span style="color:navy>'''Characteristics of HRP2 to be aware of'''</span>
A much more effective test of cure as the antigen is cleared more rapidly after effective treatment
Less affected by prozne and no mutation

Latest revision as of 10:29, 1 August 2024