Pan-malarial LDH: Difference between revisions
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<span style="font-size:90%">>>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br> | <span style="font-size:90%">>>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br> | ||
<span style="font-size:90%">>>>[[RDT_test:_antigens|RDT test antigens]]</span></br> | <span style="font-size:90%">>>>[[RDT_test:_antigens|RDT test antigens]]</span></br> | ||
<span style="font-size:90%">>>>Current page: '''The | <span style="font-size:90%">>>>Current page: '''The pan-malarial LDH antigen''' | ||
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{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal" | {| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal" | ||
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Pan-malarial | |colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Pan-malarial LDH antigen''' - practicalities'''</span> | ||
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(1) A malarial species may be present that would not be detected by the species-specific antibody. The pan-malarial antibody may detect that species.</br> | (1) A malarial species may be present that would not be detected by the species-specific antibody. The pan-malarial antibody may detect that species.</br> | ||
(2) If the species-specific antibody gives a false negative result (for example, [[False negative results and HRP2 gene deletion|gene deletion]] or [[False negative results and the prozone effect|prozone effect]]) then the pan-malarial antibody may still allow the infection to be detected. | (2) If the species-specific antibody gives a false negative result (for example, [[False negative results and HRP2 gene deletion|gene deletion]] or [[False negative results and the prozone effect|prozone effect]]) then the pan-malarial antibody may still allow the infection to be detected. | ||
''' - practicalities'''</span> | |||
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'''Background:'''</br> Plasmodium aldolase (Paldolase) and plasmodium lactate dehydrogenase (PLDH) are part of glycolysis pathways in all malaria species. Since malaria parasites have specific forms, antibodies do not cross-react with human aldolase or LDH. Antibodies to these proteins may potentially recognise all species of malaria and are known as “pan-malaria specific antibodies”. These are:</br> | |||
*Plasmodium lactate dehydrogenase (PpanLDH) | |||
*Plasmodium aldolase (Paldolase) | |||
Latest revision as of 12:51, 3 October 2024
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>>RDT main page
>>>RDT test antigens
>>>Current page: The pan-malarial LDH antigen
| Pan-malarial LDH antigen - practicalities
Background:
Use of Pan-malarial antifgens in RDT tests Outside of Africa, the most frequently used form of malaria RDT combines a species-specific with a pan-species antibody e.g. HRP2/LDH or HRP2/aldolase Use in malaria testing Their use in combination tests is helpful when: Background:
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