Actions

Emerging strategies and options: Difference between revisions

From MalariaETC

No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 2: Line 2:
----
----
'''Navigation'''</br>
'''Navigation'''</br>
<span style="font-size:90%">[[MalariaETC Index|1. Main Malaria Index]]''</span></br>
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br>
<span style="font-size:90%">[[Rapid diagnostic tests (RDTs)|2. RDT main page]]''</span></br>
<span style="font-size:90%">[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
<span style="font-size:90%">[[RDT_test:_formats_of_tests|3. RDT Test Design]]''</span></br>
<span style="font-size:90%">>[[RDT_test:_formats_of_tests|RDT Test Design]]''</span></br>
<span style="font-size:90%">Current page: '''Emerging Strategies for RDT Design'''</span>
<span style="font-size:90%">>>Current page: '''New RDT Design strategies'''</span>
----
----


Line 12: Line 12:
----
----
<span style="font-size:90%">'''Multiplexed detection strategies'''  
<span style="font-size:90%">'''Multiplexed detection strategies'''  
</br>These may be used in some circumstances to optimise performance according to local requirements:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
</br>These may be used in some circumstances to optimise performance according to local requirements:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pan-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
|}
|}

Latest revision as of 10:25, 30 September 2024

Navigation
Main Malaria Index
 RDT main page
 >RDT Test Design
 >>Current page: New RDT Design strategies

Emerging Strategies for RDT design

Multiplexed detection strategies
These may be used in some circumstances to optimise performance according to local requirements:

(a) Where both P.falciparum and P.vivax are highly prevalent, then tests with specificity for each species may prove valuable - P.falciparum (HRP2) and P.vivax (Pv-pLDH) may be combined with or without a pan-specific antibody. This can offer some advantages in detecting dual infection by the two species.

(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.

Retrieved from "https://haematologyetc.org/index.php?title=Emerging_strategies_and_options&oldid=795"