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<span style="font-size:90%">[[RDT test: formats of tests|Return to RDT format page]]</span>
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'''Navigation'''</br>
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br>
<span style="font-size:90%">[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
<span style="font-size:90%">>[[RDT_test:_formats_of_tests|RDT Test Design]]''</span></br>
<span style="font-size:90%">>>Current page: '''New RDT Design strategies'''</span>
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|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''EXTRA'''</br>span style="color:navy>Emerging Strategies for RDT design'''</span>
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Emerging Strategies for RDT design'''</span>
 
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<span style="font-size:90%">'''Multiplexed detection strategies'''  
<span style="font-size:90%">'''Multiplexed detection strategies''' may be used in some circumstances to optimase performance for local need:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pen-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
</br>These may be used in some circumstances to optimise performance according to local requirements:</br></br> (a) Where both ''P.falciparum'' and ''P.vivax'' are highly prevalent, then tests with specificity for each species may prove valuable -  ''P.falciparum'' (HRP2) and ''P.vivax'' (Pv-pLDH) may be combined with or without a pan-specific antibody. This can offer some advantages in detecting dual infection by the two species.</br></br>(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.
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Latest revision as of 10:25, 30 September 2024

Navigation
Main Malaria Index
 RDT main page
 >RDT Test Design
 >>Current page: New RDT Design strategies

Emerging Strategies for RDT design

Multiplexed detection strategies
These may be used in some circumstances to optimise performance according to local requirements:

(a) Where both P.falciparum and P.vivax are highly prevalent, then tests with specificity for each species may prove valuable - P.falciparum (HRP2) and P.vivax (Pv-pLDH) may be combined with or without a pan-specific antibody. This can offer some advantages in detecting dual infection by the two species.

(b) Where HRP2 deletion are frequent, they may cause a high risk for test failure, tests multiplexed to select for Pf-pLDH and HRP2 may improve detection in these circumstances.

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