Prozone like effect Index: Difference between revisions
From MalariaETC
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{DISPLAYTITLE:<span style="position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);">{{FULLPAGENAME}}</span>}} | {{DISPLAYTITLE:<span style="position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);">{{FULLPAGENAME}}</span>}} | ||
---- | ---- | ||
{| class="wikitable" style="width: 60%; border-style: none; border-width: 0px; border-color: gainsboro; color:black" | |||
<span style="font-size: | |style = "font-size:110%; color:black; background: gainsboro |'''Navigation'''</br> | ||
|- | |||
|<span style="font-size:110%">>[[Index|Previous Page]]''</span></br> | |||
|- | |||
|} | |||
---- | ---- | ||
| Line 10: | Line 14: | ||
<span style="font-size:90%"> | <span style="font-size:90%">More correctly the "prozone-like" or "postzone" phenomenon* is a very rare, but recognised effect that causes false negative results of tests. | ||
---- | ---- | ||
<span style="font-size:90%">Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.</br></br>*'''Note''' the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen as in this case.</span> | <span style="font-size:90%">Most often the prozone-like effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.</br></br>*'''Note''' the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen as in this case.</span> | ||
Latest revision as of 10:25, 17 December 2024
| Navigation |
| >Previous Page |
| The prozone-like (postzone) phenomenon
Most often the prozone-like effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. |