Prozone effect: Difference between revisions
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(Created page with "The Prozone effect A very rare, but recognised effect, most often this affects HRP2 antigens and means that in very high parasitaemia (causing excess antigen), the formation of appropriate antibody-antigen complexes is prevented causing the test to appear negative.") |
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'''Navigation'''</br> | |||
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br> | |||
<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br> | |||
<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br> | |||
<span style="font-size:90%">>>>Current page: '''The prozone-like effect'''</span> | |||
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|colspan="1" style = "font-size:110%; color:blasck; background: FFFAFA"|<span style="color:navy>'''The prozone-like (postzone) phenomenon'''</span> | |||
<span style="font-size:90%">Moew correctly the "prozone-like" or "postzone" phenomenon* is a very rare, but recognised effect that causes false negative results of tests. | |||
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<span style="font-size:90%">Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a '''very high parasitaemia''' (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.</br></br>*'''Note''' the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen as in this case.</span> | |||
Latest revision as of 15:25, 21 November 2024
Navigation
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>RDT main page
>>Single Band Tests
>>>Current page: The prozone-like effect
| The prozone-like (postzone) phenomenon
Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a very high parasitaemia (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly. |