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False positive reaction in RDT tests: Difference between revisions

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<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br>
<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br>
<span style="font-size:90%">>>>Current page: '''Reasons for Test Failure'''</span>
<span style="font-size:90%">>>>Current page: '''False positive reactions'''</span>
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|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Cross-reactive antibodies'''
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Cross-reactive antibodies'''


Cross-reactive antibodies are antibodies that interfere with RDT tests to cause a band to appear in the absence of a malaria infection - a "false positive". They are though to ariase as a result as a result of them forming an immune complex with labelled test antibodies and the antibodies of the detection line - so causing a band to appear in the test area in the absence of a malarial infection.  
</br><span style="font-size:90%">Cross-reactive antibodies are antibodies that interfere with RDT tests to cause a band to appear in the absence of a malaria infection - a "false positive". They are thought to arise as a result as a result of them forming an immune complex with both labelled test antibodies and the antibodies that produce detection line - so causing a band to appear in the test area in the absence of a malarial infection.  


These cross-reactive antibodies may arise following infection with another tropical organisms, or may be "polyreactive antibodies" found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse antibody (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer.
<span style="font-size:90%">These cross-reactive antibodies may arise following infection with another tropical organisms, or may be "polyreactive antibodies" found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse antibody (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer.

Latest revision as of 13:35, 21 November 2024

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Cross-reactive antibodies


Cross-reactive antibodies are antibodies that interfere with RDT tests to cause a band to appear in the absence of a malaria infection - a "false positive". They are thought to arise as a result as a result of them forming an immune complex with both labelled test antibodies and the antibodies that produce detection line - so causing a band to appear in the test area in the absence of a malarial infection.

These cross-reactive antibodies may arise following infection with another tropical organisms, or may be "polyreactive antibodies" found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse antibody (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer.

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