Actions

False positive reaction in RDT tests: Difference between revisions

From MalariaETC

No edit summary
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{DISPLAYTITLE:<span style="position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);">{{FULLPAGENAME}}</span>}}
----
----
'''Navigation'''</br>
'''Navigation'''</br>
[[Interpretation guide: SINGLE BAND tests|Go Back]]
<span style="font-size:90%">[[MalariaETC Index|Main Malaria Index]]''</span></br>
<span style="font-size:90%">>[[Rapid diagnostic tests (RDTs)|RDT main page]]''</span></br>
<span style="font-size:90%">>>[[Interpretation guide: SINGLE BAND tests|Single Band Tests]]''</span></br>
<span style="font-size:90%">>>>Current page: '''False positive reactions'''</span>
----
----


'''Cross-reactive antibodies'''
{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal"
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Cross-reactive antibodies'''


Cross-reactive antibodies may cause a "false positive" result by forming an immune complex with labelled test antibodies and the detection line that causes a band to appear in the test area.  
</br><span style="font-size:90%">Cross-reactive antibodies are antibodies that interfere with RDT tests to cause a band to appear in the absence of a malaria infection - a "false positive". They are thought to arise as a result as a result of them forming an immune complex with both labelled test antibodies and the antibodies that produce detection line - so causing a band to appear in the test area in the absence of a malarial infection.  


These cross-reactive antibodies arise following other infection (usually tropical organisms), but may also be polyreactive antibodies found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer.
<span style="font-size:90%">These cross-reactive antibodies may arise following infection with another tropical organisms, or may be "polyreactive antibodies" found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse antibody (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer.
 
----

Latest revision as of 13:35, 21 November 2024

Navigation
Main Malaria Index
 >RDT main page
 >>Single Band Tests
 >>>Current page: False positive reactions

Cross-reactive antibodies


Cross-reactive antibodies are antibodies that interfere with RDT tests to cause a band to appear in the absence of a malaria infection - a "false positive". They are thought to arise as a result as a result of them forming an immune complex with both labelled test antibodies and the antibodies that produce detection line - so causing a band to appear in the test area in the absence of a malarial infection.

These cross-reactive antibodies may arise following infection with another tropical organisms, or may be "polyreactive antibodies" found in individuals in the general population, particularly rheumatoid factor (RF) or human anti-mouse antibody (HAMA). The frequency with which such reactions occur depends considerably on the test manufacturer.

Retrieved from "https://haematologyetc.org/index.php?title=False_positive_reaction_in_RDT_tests&oldid=1249"