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<span style="font-size:90%">>>>Current page: '''Reasons for Test Failure'''</span>
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|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|<span style="color:black>'''Practical considerations and reasons for test failure'''</span>

<span style="font-size:90%">Bibliography: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652944/], [https://www.who.int/teams/global-malaria-programme/case-management/diagnosis/rapid-diagnostic-tests]</span>


<span style="font-size:90%">'''1. Selection and procurement of RDTs'''</br>

<span style="font-size:90%">(a) Quality of test design/production. Historically there was significant variation of performance between tests and batches, this has been greatly improved with the WHO pre-qualification testing program that requires a minimum standard of performant, however users are still advised to check the performance of their selected test (see WHO testing information ref 2 above)</br>(b) Lot variability. Variability between different production batches has been observed and should be considered if RDT performance is less good than expected.</br>

<span style="font-size:90%">'''2. Stability and storage issues'''</br>

<span style="font-size:90%">(a) RDTs typically have a shelf-life of 18–24 months providing storage is appropriate.</br>(b) Tests can suffer degradation if stored in inappropriate heat or humidity: generally tests are stable in the range 2–30°C or higher, but these limits may be exceeded in many countries, and continuous product refrigeration to the point of use may not be guaranteed in developing countries.

<span style="font-size:90%">'''3. Operator training'''</br>

<span style="font-size:90%">(a) Problems in test usage may include inappropriate placement of test reagents or blood sample on RDT.</br>(b) Poor interpretation of faint lines.</br>(c) Inadequate training or reference materials